Book review

Six hundred pages that will tell you more about yourself and your future than anything else

Few books pack as much science with as much intimacy as Siddhartha Mukherjee’s ‘The Gene’.

Siddhartha Mukherjee’s The Gene: An Intimate History is an extraordinarily riveting book. It is easy to forget you are reading a densely packed account of the gene. There is a phenomenal amount of technical information packed in, with many anecdotes, some personal, inserted judiciously into the narrative.

Across 600-plus pages, Pulitzer Prize winner Mukherjee (The Emperor of All Maladies: A Biography of Cancer) narrates the story of the discovery of genes, the evolution of genetics as a scientific discipline, and the rapid strides this science has made in about a century. Consider this. The term “gene”, coined by the monk Gregor Mendel in the nineteenth century was all but lost for more than six decades, only to be revived in early twentieth century, after which it became a common term.

A few decades later it led to the coining of “genocide” in Nazi Germany.

Half a century later, the helical structure of DNA & RNA was discovered. Two decades later, questions were being raised about the ethics of genetics and tinkering with genes. Yet, recombinant genes were put to use in commercial production for insulin, achieving resounding success. And by 2000, about a century from the time the word “gene” was revived, the Human Genome project was announced.

Pythagoras, Aeschylus and Plato, were convinced that the “likeness” of a human being passed on via the “mobile library” preserved in semen. Aristotle rejected this notion by astutely observing that children can inherit features from their mothers and grandmothers too. The Gene details the manner in which, over the centuries, people theorised how information was carried across generations without really understanding the mechanism or even having a name for it till Mendel’s experiments with peas and Darwin’s theories.

Mukherjee argues that the resurrection of the term was a watershed moment in the history of genetics, as suddenly there was a concatenation of events that led to furious progress in understanding the gene mechanism – coining the word, understanding the structure, exploring the mechanism, and estimating the potential.

Distortion of knowledge

Soon afterwards, the Nazis used this branch of “applied biology” to enable Rassenhygiene or “racial hygiene”, citing genetic theory to justify their policy of Lebensunwertes Leben or “lives unworthy of living” and the establishment of extermination centres such as Hadamar and the Brandenburg State Welfare Institute. Their notion was based on the premise that identity was fixed by genetic make-up.

Curiously enough, another ideological position in existence at the same time in Soviet Russia viewed the principle of heredity as having its basis in complete pliability. In both cases, science was deliberately distorted to support state-sponsored mechanisms of “cleansing”.

These twisted applications were overshadowed by rapid advancement in genetics, leading to, inter alia, the discovery of recombinant DNA, which helped create crucial medicines such as insulin, the ability to clone creatures as with Dolly the Sheep.

Not surprisingly, questions began to be asked about the ethical aspects of genetics. These questions feature prominently in Mukherjee’s examination, as he weighs the implications of using genome engineering to “enhance” humans, asking if it’s a good idea.

Uncovering truths

It has been an extraordinary period of success for curious and imaginative scientists trying to understand the principles of heredity, what makes it tick, what information gets passed on from generation to generation, what is gained and what is lost in evolution — always striving to push the boundaries to ask more and more questions.

To a lay reader, The Gene is a brilliant historical overview, but it also does a fantastic job of reinstating Rosalind Franklin as one of the four scientists responsible for discovering the helical structure of DNA. A fact that had been lost in history for some decades even when the Nobel Committee conferred the prize on Watson and Crick.

It is only recently that Rosalind Franklin’s name has been mentioned alongside Watson and Crick’s. Mukherjee lays down the facts of their experiments and analysis in a way that makes it evident that the scientists were working simultaneously on the same subject, albeit not together.

What began as an attempt to understand the reasons for “madness” that seems to exist in his family, led to an absorbing account of the “triggers” that are responsible for mapping information and carrying it from generation to generation. The Gene is outstanding for the manner in which it weaves the author’s precise scientific temper, offering technical information, with factually accurate and significant contemporary events. Siddharth Mukherjee puts forth a magnificently rich historical narrative of the gene, the truth that hides within each of us.

The Gene: An Intimate History, Siddhartha Mukherjee, Hamish Hamilton.

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Harvard Business School’s HBX brings the future of business education to India with online programs

HBX is not only offering courses online, but also connecting students to the power of its network.

The classic design of the physical Harvard Business School (HBS) classroom was once a big innovation – precisely designed teaching amphitheaters laid out for every student to participate from his or her seat with a “pit” in the center of the room from which professors orchestrate discussions analyzing business cases like a symphony lead. When it came to designing the online experience of HBX—the school’s digital learning initiative—HBS faculty worked tirelessly to blend these tenets of the HBS classroom pedagogy with the power of new technology. With real-world problem solving, active learning, and social learning as its foundation, HBX offers immersive and challenging self-paced learning experiences through its interactive online learning platform.

Reimagining digital education, breaking the virtual learning mold

Typically, online courses follow a one-way broadcast mode – lectures are video recorded and reading material is shared – and students learn alone and are individually tested. Moving away from the passive learning model, HBX has developed an online platform that leverages the HBS ‘case-based pedagogy’ and audio-visual and interaction tools to make learning engaging.

HBX courses are rarely taught through theory. Instead, students learn through real-world problem-solving. Students start by grappling with a business problem – with real world data and the complexity in which a business leader would have to make a decision – and learn the theory inductively. Thus even as mathematical theories are applied to business situations, students come away with a greater sense of clarity and perspective, whether it is reading a financial report, understanding why a brand’s approach to a random sample population study may or may not work, or how pricing works.

HBX Platform | Courses offered in the HBX CORe program
HBX Platform | Courses offered in the HBX CORe program

“Learning about concepts through real-life cases was my favorite part of the program. The cases really helped transform abstract concepts into observable situations one could learn from. Furthermore, it really helped me understand how to identify situations in which I could use the tools that HBX equipped me with,” says Anindita Ravikumar, a past HBX participant. India’s premier B-school IIM-Ahmedabad has borrowed the very same pedagogy from Harvard. Learning in this manner is far more engaging, relatable, and memorable.

Most lessons start with a short 2-3 minute video of a manager talking about the business problem at hand. Students are then asked to respond on how they would handle the issue. Questions can be in the form of either a poll or reflections. Everyone’s answers are then visible to the ‘classroom’. In the words of Professor Bharat Anand, Faculty Chair, HBX, “This turns out to be a really important distinction. The answers are being updated in real-time. You can see the distribution of answers, but you can also see what any other individual has answered, which means that you’re not anonymous.” Students have real profiles and get to know their ‘classmates’ and learn from each other.

HBX Interface | Students can view profiles of other students in their cohort
HBX Interface | Students can view profiles of other students in their cohort

Professor Anand also says, “We have what we call the three-minute rule. Roughly every three minutes, you are doing something different on the platform. Everyone is on the edge of their seats. Anyone could be called on to participate at any time. It’s a very lean forward mode of learning”. Students get ‘cold-called’ – a concept borrowed from the classroom – where every now and then individuals will be unexpectedly prompted to answer a question on the platform and their response will be shared with other members of the cohort. It keeps students engaged and encourages preparedness. While HBX courses are self-paced, participants are encouraged to get through a certain amount of content each week, which helps keep the cohort together and enables the social elements of the learning experience.

More than digital learning

The HBS campus experience is valued by alumni not just for the academic experience but also for the diverse network of peers they meet. HBX programs similarly encourage student interactions and opportunities for in-person networking. All HBXers who successfully complete their programs and are awarded a credential or certificate from HBX and Harvard Business School are invited to the annual on-campus HBX ConneXt event to meet peers from around the world, hear from faculty and business executives, and also experience the HBS campus near Cambridge.

HBXers at ConneXt, with Prof. Bharat Anand
HBXers at ConneXt, with Prof. Bharat Anand

Programs offered today

HBX offers a range of programs that appeal to different audiences.

To help college students and recent graduates prepare for the business world, HBX CORe (Credential of Readiness) integrates business essentials such as analytics, economics, and financial accounting. HBX CORe is also great for those interested in an MBA looking to strengthen their application and brush up their skills to be prepared for day one. For working professionals, HBX CORe and additional courses like Disruptive Strategy, Leading with Finance, and Negotiation Mastery, can help deepen understanding of essential business concepts in order to add value to their organizations and advance their careers.

Course durations range from 6 to 17 weeks depending on the program. All interested candidates must submit a free, 10-15 minute application that is reviewed by the HBX admissions team by the deadlines noted on the HBX website.

For more information, please review the HBX website.

This article was produced by the Scroll marketing team on behalf of HBX and not by the Scroll editorial team.