Five-time champion Roger Federer set-up a mouthwatering US Open quarter-final clash against 2009 winner Juan Martin del Potro on Monday.

Third seed Federer defeated Philipp Kohlschreiber 6-4, 6-2, 7-5 to take his record over the German to 12-0.

Del Potro, who defeated Federer in the 2009 final for his only Grand Slam title, saved two match points to knock out Austrian sixth seed Dominic Thiem 1-6, 2-6, 6-1, 7-6(1), 6-4 in his fourth-round match.

Federer’s ‘bum’ note

Federer has a 16-5 advantage over Del Potro but they have split their last six meetings.

The 36-year-old Swiss maestro didn’t face a break point against Kohlschreiber with his biggest challenge having to take a medical time-out off court at the end of the second set.

“I needed a rub on my back or bottom and I didn’t want to do it in front of you guys,” he explained before he turned his attentions to Del Potro.

“It’s great to see him back on tour. He’s had a rough ride with wrist problems. He’s a good guy.”