The world’s sports court will decide on Wednesday in the case of South African runner Caster Semenya’s challenge against rules regulating testosterone in female athletes — a verdict expected to have a profound impact on the future of women’s sport.

Semenya, a double Olympic champion, is fighting regulations imposed by the International Association of Athletics Federations that compel “hyperandrogenic” athletes – or those with “differences of sexual development” (DSD) – to lower their testosterone levels if they wish to compete as women.

The IAAF says the rules are essential to preserve a level playing field and ensure that all female athletes can see “a path to success.”

But Semenya’s cause has earned widespread support, including by a global coalition of nations and scientific experts who argue that testosterone is an arbitrary and unfair measure for determining gender.

READ: Why Caster Semenya v IAAF ruling will be critical for women’s participation in sport

The Court of Arbitration for Sport in Lausanne, Switzerland heard a week of arguments in the case in February. A panel of three arbitrators is due to deliver its verdict on Wednesday at 12:00 pm (1000 GMT.)

Semenya, who has dominated the 800m race over the last decade, has remained largely silent through the court battle, excluding statements from her legal team condemning the IAAF’s tactics and policies.

But scores of others have vocally rallied behind her.

In a rare intrusion into the world of sport, the United Nations Human Rights Council adopted a resolution last month branding the IAAF rules “unnecessary, humiliating and harmful.”

With unanimous support from the council’s 47 member-states representing every continent, the resolution marked a stunning rebuke for the IAAF.

Tennis legend Martina Navratilova is among a long-list of athletes who have backed Semenya.

But her most fervent support has come from her native South Africa, where the government has accused the IAAF of seeking to violate women’s bodies and levelled racism charges against the athletics governing body.

Experts have meanwhile argued that barring certain women from competition due to naturally high testosterone levels would be like excluding basketball players because they are too tall.

Multiple scientists have noted that achieving excellence in sport is a combination of training, commitment as well as genetics and that excluding people from competition over a single genetic factor has no scientific basis.

‘Fair competition’

However, the IAAF is not alone with athletes of the calibre of World marathon record-holder Paula Radcliffe backing the world body.

“It’s a very, very difficult and complex situation and I don’t feel there is an outcome that is perfectly fair to everybody,” the now-retired British runner told AFP last month. But she said she believed the IAAF “are trying to protect female sport and create fair competition.”

The IAAF rules capping testosterone levels in women athletes at five nanomoles per litre (nmol/L) of blood were instituted in November 2018 but have been suspended pending Wednesday’s verdict.

The IAAF, led by British track champion Sebastian Coe, has maintained that its case is simply about fairness.

DSD athletes with male levels of testosterone “get the same increases in bone and muscle size and strength and increases in haemoglobin that a male gets when they go through puberty,” the federation has said.

Ensuring that all women athletes have female levels of testosterone is therefore necessary “to preserve fair competition in the female category,” it added.

Semenya’s testosterone levels are not publicly known, but if the IAAF rules are approved she is likely not the only athlete who will be affected.

The two athletes who finished behind her in the Rio Olympics 800m, Francine Niyonsaba of Burundi and Kenya’s Margaret Wambui, have also faced questions about their testosterone levels.