US Open semi-finalist Daniil Medvedev was knocked out in the first round of the Hamburg ATP event on Tuesday by world number 41 Ugo Humbert.
Humbert of France sent the top seed packing with a 6-4, 6-3 upset in the last tournament before the rescheduled French Open starts on Sunday.
This was the 22-year-old’s first top 10 scalp. Russian Medvedev, who was beaten by eventual US Open winner Dominic Thiem in New York this month, is ranked fifth.
Humbert has emerged as the main home hope for Roland Garros. Compatriot Gael Monfils lost earlier on the Hamburg clay 6-4, 6-3 by Yannick Hanfmann.
Monfils, ranked ninth in the world, lost 6-4, 6-3 to world number 103 Hanfmann, who had never beaten a top-10 player before.
The 28-year-old German will face Chile’s Cristian Garin in the next round.
Humbert next faces Czech Jan Vesely, who beat another French player, Gilles Simon, on Monday.
Ugo Humbert (FRA) bt Daniil Medvedev (RUS x1) 6-4, 6-3
Fabio Fognini (ITA x6) bt Philipp Kohlschreiber (GER) 4-6, 6-1, 7-5
Roberto Bautista (ESP x4) bt Nikoloz Basilashvili (GEO) 6-4, 6-3
Dominik Koepfer (GER) bt Yoshihito Nishioka (JPN) 7-6 (7/0), 4-6, 6-1
Alexander Bublik (KAZ) bt Albert Ramos (ESP) 6-2, 7-6 (7/5)
Felix Auger-Aliassime (CAN) bt Lorenzo Sonego (ITA) 6-2, 7-6 (7/2)
Christian Garin (CHI) bt Kei Nishikori (JPN) 6-0, 6-3
Yannick Hanfmann (GER) bt Gael Monfils (FRA x3) 6-4, 6-3
Karen Khachanov (RUS x8) bat Jan-Lennard Struff (GER) 7-6 (7/5), 4-6, 7-5
Dusan Lajovic (SRB) bt Adrian Mannarino (FRA) 6-4, 6-1
With AFP Inputs