Research Digest

Lab notes: Researchers decipher antibacterial mechanism of naturally occurring chemical

The discovery can aid development of new antibiotics.

Researchers at the Indian Institute of Technology, Roorkee, have found out the mechanism that underlies antibacterial properties of a natural compound called chlorogenic acid which occurs in several plants including coffee.

They have shown that the compound binds itself to an enzyme called chlorismate mutase in bacteria, thereby inhibiting its growth and causing its eventual death. The enzyme is in Shikimate pathway, which is one of the most essential metabolic pathways in any bacteria. It provides amino acids essential for survival of bacteria.

The shikimate pathway is present in microorganisms, plants, and apicomplexan parasites, but is absent in higher eukaryotes, which makes the enzymes of this pathway promising targets for the development of antibiotics, herbicides and pesticides.

Dr Pravindra Kumar of the Department of Biotechnology at the Institute said, “Based on biochemical and structural findings, we have shown that chlorogenic acid, a structural analogue of chorismic acid, is an inhibitor of chorismate mutase. Biochemical and binding assays have shown the inhibitory activity of chlorogenic acid against chorismate mutase type II.”

The researchers claim that molecular mechanism of antibacterial properties of chlorogenic acid has been deciphered for the first time. “The overall structural blueprints obtained from our work can be exploited to produce a more efficient new class of antibiotics. The atomic resolution structural snapshot of the Chlorogenic Acid binding with Chlorismate Mutase enzyme provides information, which can be used to tweak the chemical structure of Chlorogenic Acid to make a more potent inhibitor,” Kumar added. The first results of the study were published in Scientific Reports last year.

The research team included Dr.Shivendra Pratap, Dr Aditya Dev, Dr Vijay Kumar, Dr Ravi Yadav, Dr Manju Narwal and Dr Shaily Tomar.

This article was first published by India Science Wire.

We welcome your comments at
Sponsored Content BY 

Why should inclusion matter to companies?

It's not just about goodwill - inclusivity is a good business decision.

To reach a 50-50 workplace scenario, policies on diversity need to be paired with a culture of inclusiveness. While diversity brings equal representation in meetings, board rooms, promotions and recruitment, inclusivity helps give voice to the people who might otherwise be marginalized or excluded. Inclusion at workplace can be seen in an environment that values diverse opinions, encourages collaboration and invites people to share their ideas and perspectives. As Verna Myers, a renowned diversity advocate, puts it “Diversity is being invited to the party, inclusion is being asked to dance.”

Creating a sense of belonging for everyone is essential for a company’s success. Let’s look at some of the real benefits of a diverse and inclusive workplace:

Better decision making

A whitepaper by Cloverpop, a decision making tool, established a direct link between inclusive decision making and better business performance. The research discovered that teams that followed an inclusive decision-making process made decisions 2X faster with half the meetings and delivered 60% better results. As per Harvard Business School Professor Francesca Gino, this report highlights how diversity and inclusion are practical tools to improve decision making in companies. According to her, changing the composition of decision making teams to include different perspectives can help individuals overcome biases that affect their decisions.

Higher job satisfaction

Employee satisfaction is connected to a workplace environment that values individual ideas and creates a sense of belonging for everyone. A research by Accenture identified 40 factors that influence advancement in the workplace. An empowering work environment where employees have the freedom to be creative, innovative and themselves at work, was identified as a key driver in improving employee advancement to senior levels.


A research by stated the in India, 62% of innovation is driven by employee perceptions of inclusion. The study included responses from 1,500 employees from Australia, China, Germany, India, Mexico and the United States and showed that employees who feel included are more likely to go above and beyond the call of duty, suggest new and innovative ways of getting work done.

Competitive Advantage

Shirley Engelmeier, author of ‘Inclusion: The New Competitive Business Advantage’, in her interview with Forbes, talks about the new global business normal. She points out that the rapidly changing customer base with different tastes and preferences need to feel represented by brands. An inclusive environment will future-proof the organisation to cater to the new global consumer language and give it a competitive edge.

An inclusive workplace ensures that no individual is disregarded because of their gender, race, disability, age or other social and cultural factors. Accenture has been a leading voice in advocating equal workplace. Having won several accolades including a perfect score on the Human Rights Campaign’s Corporate equality index, Accenture has demonstrated inclusive and diverse practices not only within its organisation but also in business relationships through their Supplier Inclusion and Diversity program.

In a video titled ‘She rises’, Accenture captures the importance of implementing diverse policies and creating an inclusive workplace culture.


To know more about inclusion and diversity, see here.

This article was produced by the Scroll marketing team on behalf of Accenture and not by the Scroll editorial team.