In the wake of six deaths and 380 cases of confirmed and probable lung disease across the US, the Trump administration has called for the banning of most flavored e-cigarettes because of their huge appeal to young people.
The Centers for Disease Control and Prevention is looking closely at the different flavoured nicotine juices and other substances users may be vaping in e-cigarettes to determine how the aerosol might be affecting users’ lungs.
On September 12, the Centers for Disease Control and Prevention lowered the number of confirmed and probable cases from more than 400 to 380. The number was lower, the agency said, because it is no longer reporting “possible cases.”
The mystery and concern remain. And, many smokers who use these devices to quit are concerned that a valuable tool may be taken away from them.
There’s much more that researchers need to know. These devices have a short history. As an engineer who studies how people use tobacco products, I believe that users’ behaviour is key to understanding the positive and negative health effects resulting from e-cigarettes. After all, their intent was to help people stop smoking, the number one cause of preventable death in the US.
The way users puff, how long they puff and what they puff all play a role. We do not yet know how this behaviour affects how much of each substance vapers consume over the course of their daily lives, but we have reason to believe it is significant.
A failed promise
Many are sceptical that e-cigarettes will reduce death rates related to smoking. Historically safer cigarettes have not delivered on a similar promise. After the US surgeon general declared smoking harmful in 1964, smokers who could not quit migrated to what were then considered low-yield cigarettes, marketed as safer and having less tar than regular cigarettes.
But the wide use of low-yield cigarettes did not lower death rates for smokers. Cases of squamous cell lung cancer did decrease after the surgeon general’s warning, but another type, adenocarcinoma, increased.
Engineering models suggest that changes in smoke characteristics combined with smokers’ compensating behaviours changed where the particles deposited in the lung played a role. Smokers may have consumed more smoke to maintain their addiction. Different cancer types originate in different lung locations. The thought is that smokers changed their behaviour, and in doing so, may have traded one type of cancer for another.
How did we miss this?
Traditionally, cigarettes were tested in a laboratory, using smoking machines – not a smoker – using an industry-standard protocol established in 1966. Research later revealed that this mechanised smoking does not represent realistic behaviour and so, did not represent realistic exposure to harmful constituents. The former standard – the FTC/ISO puffing protocol – was repealed in 2008, with the hope that a new, more realistic standard would take its place.
Now, thanks to a law passed in 2009, tobacco product manufacturers cannot claim reduced risk without scientific evidence. Researchers like me are applying lessons learned from the low-tar debacle and generating scientific evidence to understand the true health impact of e-cigarettes.
No regulatory authority
Since e-cigarettes entered the market in Europe in 2006, demand increased from those hoping to quit cigarettes to those who have never smoked, including an unusually high number of young people. This has raised concerns. Is vaping a gateway for youth to start smoking? Do young people use e-cigarettes in a different way than adults?
In June, the FDA released guidelines for e-cigarette manufacturers, recognising the significant role behaviour plays in determining whether or not a product poses a health threat. The guidelines call for an assessment of how individual users consume the product, including such things as the number of puffs, puff duration, puff intensity and the frequency of use.
This behaviour data is very important for many reasons. Users may adopt behaviour that nullifies any anticipated health effect based on lab tests. A puff generated in the lab may contain less nicotine, but the user may simply take more puffs during the day to achieve their nicotine addiction and so consume more toxins than expected.
Other potential dangers
Researchers and physicians also need to know what substances are being vaped and also various device designs. The US Food and Drug Administration maintains a list called harmful and potentially harmful constituents, or HPHCs, based on data related to traditional cigarette smoking, but less is known about the effect of product designs. Users can tamper with the various modular devices, which could change their effects. Teens may be particularly likely to toy with devices.
The FDA is currently updating the list to include ingredients that might be found in e-cigarettes. Nicotine is already on the list, as well as various metals and other non-nicotine substances.
The liquids used to deliver the nicotine could be a problem. The base, or e-liquids, typically made of a combination of vegetable glycerine and propylene glycol, may alone cause an inflammatory response in the lung, even if flavour additives are banned.
And with regard to flavours, it is important to understand that the toxicity of a substance may be different if it is inhaled versus ingested. For example, vanilla flavouring may be deemed safe for eating, but it may not be safe for vaping. Some flavourings decompose when heated and generate molecules that are not in the base e-liquid.
Would reducing the intake of flavourings also reduce harmful effects? And how much of these additives can be consumed before harmful effects materialised? Or, alternatively, how much must be reduced before health benefits can be realised?
The regulatory process
By reenacting vaping behaviour in the lab, those of us who study design and behaviour can better understand the nature of the constituents being consumed.
What have we have found so far?
- Puff flow rate alters the nature of the aerosol, so users can control the strength of each puff simply by altering the way they puff.
- E-cigarette users change their puffing flow rate when they switch flavours or nicotine levels and are altering their exposure to harmful or potentially harmful constituents.
- For a given e-cigarette brand and flavour, there is a wide range of user behaviours, such as puff flow rates and puff duration.
- Machine replays of vapour behaviours show exposure varies over a wide range for any given product.
- Some e-cigarette users puff all day long, whereas others puff in more discrete time intervals, similar to smoking.
- Even if there is less nicotine per puff in some cases for e-cigarettes compared to cigarettes, e-cigarette users can indeed consume the same amount or more nicotine in a day compared to smoking.
We and other researchers aim to continue studying how new e-cigarette products are being used so manufacturers can develop safer products, and the FDA can develop meaningful regulations, so the consumer, in consultation with their physician, can make informed decisions.
Risa Robinson is a Professor and Department Chair of Mechanical Engineering at the Rochester Institute of Technology.
This article first appeared on The Conversation.