Rafael Nadal launched his tilt at a fourth US Open title Tuesday with a swift defeat of John Millman as other leading seeds in his half of the draw tumbled out in the first round.

Four players in the world’s top 10 – Dominic Thiem, Stefanos Tsitsipas, Karen Khachanov and Roberto Bautista Agut – lost Tuesday to ease Nadal’s potential path to the final.

The Spanish second seed – US Open champion in 2010, 2013 and 2017 – needed barely two hours to see Millman off 6-3, 6-2, 6-2 at Arthur Ashe Stadium with the world number 60 from Australia unable to reproduce the magic that saw him stun Roger Federer here a year ago.

“The beginning, the first match, is always a little bit new even if I’ve played here plenty of times,” said Nadal, who meets Aussie Thanasi Kokkinakis next. “I think I played well and in general am very happy with the way I started.

“He (Millman) showed last year what he’s able to do when he’s doing well and I came on court with a lot of respect.”

Two-time French Open runner-up Thiem was upset by Italian giant-killer Thomas Fabbiano 6-4, 3-6, 6-3, 6-2, as the Austrian slumped to another first-round exit, having lost at the same stage at Wimbledon.

“I got very tired and exhausted after two sets. I’m far away from 100 percent,” Thiem said. “It was not the real me there on the court.”

Greek eighth seed Tsitsipas struggled with cramps and accused umpires of having “preferences” after he fell to a 6-4, 6-7 (5/7), 7-6 (9/7), 7-5 defeat by Next Gen rival Andrey Rublev in a gruelling four-hour slog.

Tsitsipas, for whom it was also a second successive Grand Slam opening-round defeat, was hit with a point penalty for a time violation in the final set.

“This chair umpire, I don’t know, he has something against me. I don’t know why,” said Tsitsipas, who snapped “you’re all weirdos” at French official Damien Dumusois during his match.

“I wish that all the chair umpires were like Mohamed Lahyani because I believe he’s the best out in the game, and we need more like him in tennis because he’s fair to everyone. I feel like some of them have preferences when they are on the court.”

Russian ninth seed Khachanov lost to Canada’s Vasek Pospisil in five sets, with 10th seed Bautista Agut of Spain succumbing in similar fashion to Mikhail Kukushkin of Kazakhstan to leave that quarter of the draw wide open for Nick Kyrgios.

The volatile Australian eased past American Steve Johnson 6-3, 7-6 (7/1), 6-4 in a match that finished at 1:12 a.m. local time.

Alexander Zverev, seeded sixth, outlasted Moldova’s Radu Albot 6-1, 6-3, 3-6, 4-6, 6-2, while Marin Cilic, the 2014 champion, advanced in straight sets over Slovakia’s Martin Klizan.

Results

1st rd

Andrey Rublev (RUS) bt Stefanos Tsitsipas (GRE x8) 6-4, 6-7 (5/7), 7-6 (9/7), 7-5

Gilles Simon (FRA) bt Bjorn Fratangelo (USA) 5-7, 7-5, 7-5, 7-5

Matteo Berrettini (ITA x24) bt Richard Gasquet (FRA) 6-4, 6-3, 2-6, 6-2

Jordan Thompson (AUS) bt Joao Sousa (POR) 6-3, 6-2, 6-4

Alexei Popyrin (AUS) bt Federico Del Bonis (ARG) 6-1, 7-5, 7-6 (7/5)

Mikhail Kukushkin (KAZ) bt Roberto Bautista Agut (ESP x10) 3-6, 6-1, 6-4, 3-6, 6-3

Gael Monfils (FRA x13) bt Albert Ramos (ESP) 7-6 (7/2), 6-4, 6-3

Marius Copil (ROU) bt Ugo Humbert (FRA) 6-3, 5-7, 7-6 (13/11), 4-6, 6-1

Denis Shapovalov (CAN) bt Felix Auger-Aliassime (CAN x18) 6-1, 6-1, 6-4

Pablo Andujar (ESP) bt Kyle Edmund (GBR x30) 3-6, 7-6 (7/1), 7-5, 5-7, 6-2

Lorenzo Sonego (ITA) bt Marcel Granollers (ESP) 6-3, 6-4, 6-4

Alexander Bublik (KAZ) bt Santiago Giraldo (COL) 2-6, 6-0, 7-5, 3-6, 6-4

Thomas Fabbiano (ITA) bt Dominic Thiem (AUT x4) 6-4, 3-6, 6-3, 6-2

Alexander Zverev (GER x6) bt Radu Albot (MDA) 6-1, 6-3, 3-6, 4-6, 6-2

Frances Tiafoe (USA) bt Ivo Karlovic (CRO) 6-2, 6-3, 1-2, retired

Aljaz Bedene (SLO) bt Jozef Kovalík (SVK) 6-3, 6-4, 7-5

Benoît Paire (FRA x29) bt Brayden Schnur (CAN) 6-2, 6-4, 6-4

Diego Schwartzman (ARG x20) bt Robin Haase (NED) 6-3, 7-6 (8/6), 6-0

Egor Gerasimov (BLR) bt Lloyd Harris (RSA) 7-5, 7-6 (7/5), 7-6 (7/3)

Tennys Sandgren (USA) bt Jo-Wilfried Tsonga (FRA) 1-6, 6-7 (2/7), 6-4, 7-6 (7/5), 7-5

Vasek Pospisil (CAN) bt Karen Khachanov (RUS x9) 4-6, 7-5, 7-5, 4-6, 6-3

John Isner (USA x14) bt Guillermo Garcia-Lopez (ESP) 6-3, 6-4, 6-4

Jan-Lennard Struff (GER) bt Casper Ruud (NOR) 6-4, 6-4, 6-2

Cedrik-Marcel Stebe (GER) bt Filip Krajinovic (SRB) 6-3, 4-6, 6-4, 7-6 (8/6)

Marin Cilic (CRO x22) bt Martin Klizan (SVK) 6-3, 6-2, 7-6 (8/6)

Fernando Verdasco (ESP x32) bt Tobias Kamke (GER) 6-3, 3-6, 6-1, 6-2

Chung Hyeon (KOR) bt Ernesto Escobedo (USA) 3-6, 6-4, 6-7 (5/7), 6-4, 6-2

Thanasi Kokkinakis (AUS) bt Ilya Ivashka (BLR) 6-3, 7-6 (10/8), 6-7 (4/7), 6-2

Rafael Nadal (ESP x2) bt John Millman (AUS) 6-3, 6-2, 6-2

Antoine Hoang (FRA) bt Leonardo Mayer (ARG) 3-6, 6-2, 6-7 (6/8), 6-1, 6-3

Henri Laaksonen (SUI) bt Marco Cecchinato (ITA) 7-6 (7/3), 7-6 (8/6), 2-6, 3-6, 7-6 (7/2)

With AFP Inputs