Research Digest

Lab notes: Scientist find a gene that can protect against Alzheimer’s disease

Genetic research into Alzheimer’s disease so far has focussed on identifying risk factors and not genes that reduce risk of the disease.

Alzheimer’s researchers have found a number of genes that might increase a person’s chance of developing the neurological disorder. But is there a gene that can protect someone from Alzheimer’s? It turns out that there might be.

Medical researchers at Brigham Young University in Utah, United States have discovered a variant of a gene called RAB10 that provides a protective effect for individuals at high-risk of Alzheimer’s. Many elderly people who carry this genetic variant never acquired the disease.

The research team used data from the Utah Population Database, which is a dataset of 20 million genealogical records and historical medical records. They first identified families that had a large number of people resilient to Alzheimer’s, that is, they carried the main genetic risk factor for Alzheimer’s but remained healthy into advanced age.

The researchers then used whole genome sequencing to look for the DNA that resilient individuals shared with each other. They also identified the DNA that they did not share with family members who died of Alzheimer’s. They discovered that the common factor between the resilient subjects was a variant in the RAB10 gene while those who got the disease did not carry this variant.

The research team then carried out experiments to check the impact on Alzheimer’s disease related proteins when the RAB10 gene variant was either overexpressed or underexpressed in cells. They found that when this gene is reduced in in a person’s body, it has the potential to reduce risk for Alzheimer’s.

While there are currently no meaningful interventions for Alzheimer disease, the study authors believe this genetic function could be targeted with drugs to help reduce the risk of people getting the disease. The study was published in the journal Genome Medicine details a novel and promising approach in the effort to treat Alzheimer’s disease.

Support our journalism by subscribing to Scroll+ here. We welcome your comments at
Sponsored Content BY 

Get ready for an 80-hour shopping marathon

Here are some tips that’ll help you take the lead.

Starting 16th July at 4:00pm, Flipkart will be hosting its Big Shopping Days sale over 3 days (till 19th July). This mega online shopping event is just what a sale should be, promising not just the best discounts but also buying options such as no cost EMIs, buyback guarantee and product exchanges. A shopping festival this big, packed with deals that you can’t get yourself to refuse, can get overwhelming. So don’t worry, we’re here to tell you why Big Shopping Days is the only sale you need, with these helpful hints and highlights.

Samsung Galaxy On Nxt (64 GB)

A host of entertainment options, latest security features and a 13 MP rear camera that has mastered light come packed in sleek metal unibody. The sale offers an almost 40% discount on the price. Moreover, there is a buyback guarantee which is part of the deal.

Original price: Rs. 17,900

Big Shopping Days price: Rs. 10,900

Samsung 32 inches HD Ready LED TV

Another blockbuster deal in the sale catalogue is this audio and visual delight. Apart from a discount of 41%, the deal promises no-cost EMIs up to 12 months.

Original price: Rs. 28,890

Big Shopping Days price: Rs. 10,900

Intel Core I3 equipped laptops

These laptops will make a thoughtful college send-off gift or any gift for that matter. Since the festive season is around the corner, you might want to make use of this sale to bring your A-game to family festivities.

Original price: Rs. 25,590

Big Shopping Days price: Rs. 21,900


If you’ve been planning a mid-year wardrobe refresh, Flipkart’s got you covered. The Big Shopping Days offer 50% to 80% discount on men’s clothing. You can pick from a host of top brands including Adidas and Wrangler.

With more sale hours, Flipkart’s Big Shopping Days sale ensures we can spend more time perusing and purchasing these deals. Apart from the above-mentioned products, you can expect up to 80% discount across categories including mobiles, appliances, electronics, fashion, beauty, home and furniture.

Features like blockbuster deals that are refreshed every 8 hours along with a price crash, rush hour deals from 4-6 PM on the starting day and first-time product discounts makes this a shopping experience that will have you exclaiming “Sale ho to aisi! (warna na ho)”

Set your reminders and mark your calendar, Flipkart’s Big Shopping Days starts 16th July, 4 PM and end on 19th July. To participate in 80 hours of shopping madness, click here.


This article was produced by the Scroll marketing team on behalf of Flipkart and not by the Scroll editorial team.