Mosquito menace

In Maharashtra, a high security prison for genetically modified mosquitoes

Mahyco is one of India’s oldest hybrid seed companies. Its research facility in a village near Aurangabad in Maharashtra is packed with all the equipment needed to grow and test seedlings, from protein mixers to UV labs. And then, tucked into a corner of the facility are electric bats, like the one in the picture above, normally used to kill mosquitoes.

It’s not that Mahyco has a mosquito problem.

Further down the corridor is India’s only research centre for genetically modified mosquitoes.

Run by Gangabishan Bhikulal Investment and Trading, a sister concern of Mahyco, the company that partners with Monsanto to develop genetically modified cotton in India, the centre's research into genetically modified mosquitoes is aimed at combating dengue.

When granting approval for the lab in 2008, the Department of Biotechnology instructed GBIT to take appropriate measures to ensure their modified mosquitoes do not escape.

To escape, a mosquito will have to break through a fine net at the opening of its sealed plastic box where it lives most of its life, pass through four doors, meander down to the end of a dull windowless corridor, at the end of which is a door that leads to freedom.

Closed doors and windows are nothing to the determined insect. Hence, the bats.

Each of the three outer rooms that one must pass through to access the sanctum of mosquito cages comes with its own electric bat near the wall. This too, researchers at the facility say, is a requirement of the Department of Biotechnology. If any mosquito escapes, they are instructed to kill them.

None have, so far, researchers say.

While the lab and its technicians are Indian, the technology has been developed by Oxitec, a company set up in the United Kingdom to commercially promote research produced at Oxford University.

Their aim is to reduce the spread of dengue. The problem, in their view, is simple. Female Aedes aegypti mosquitoes spread the dengue virus. If the virus cannot be controlled by vaccines, the next logical target to reduce the incidence of the disease are the carriers of the virus.

This has indeed been the solution of public health systems until now. In the absence of effective preventive medicine, the most prominent approaches have focussed on controlling mosquito populations by limiting their breeding grounds – removing stagnant pools of water.

But instead of making mosquito reproduction inconvenient, Oxitec’s technology wants to make it impossible.

With their technology, male mosquitoes of the Aedes aegypti species will be genetically modified to carry a “kill switch” gene. When passed on to their offspring, the gene will ensure that they do not survive into adulthood.

Given that the life span of mosquitoes is only a matter of weeks, the modification could reduce mosquito population within months.

But this throws up ethical and scientific issues. What happens if female mosquitoes adapt and avoid mating with modified males? What are the implications of eradicating an entire species of mosquitoes?

“Aedes aegypti is an invasive species that is not native to India,” said Dr SK Dasgupta, the lead scientist working on this project. “So its loss will not affect the food chain here. We can reduce their population to the extent that the disease does not spread.”

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Some of the worst decisions made in history

From the boardroom to the battlefield, bad decisions have been a recipe for disaster

On New Year’s Day, 1962, Dick Rowe, the official talent scout for Decca Records, went to office, little realising that this was to become one of the most notorious days in music history. He and producer Mike Smith had to audition bands and decide if any were good enough to be signed on to the record label. At 11:00 am, either Rowe or Smith, history is not sure who, listened a group of 4 boys who had driven for over 10 hours through a snowstorm from Liverpool, play 15 songs. After a long day spent listening to other bands, the Rowe-Smith duo signed on a local group that would be more cost effective. The band they rejected went on to become one of the greatest acts in musical history – The Beatles. However, in 1962, they were allegedly dismissed with the statement “Guitar groups are on the way out”.

Source: Wikimedia Commons
Source: Wikimedia Commons

Decca’s decision is a classic example of deciding based on biases and poor information. History is full of examples of poor decisions that have had far reaching and often disastrous consequences.

In the world of business, where decisions are usually made after much analysis, bad decisions have wiped out successful giants. Take the example of Kodak – a company that made a devastating wrong decision despite overwhelming evidence to the contrary. Everyone knows that Kodak couldn’t survive as digital photography replaced film. What is so ironic that Alanis Morissette could have sung about it, is that the digital camera was first invented by an engineer at Kodak as early as 1975. In 1981, an extensive study commissioned by Kodak showed that digital was likely to replace Kodak’s film camera business in about 10 years. Astonishingly, Kodak did not use this time to capitalise on their invention of digital cameras – rather they focused on making their film cameras even better. In 1996, they released a combined camera – the Advantix, which let users preview their shots digitally to decide which ones to print. Quite understandably, no one wanted to spend on printing when they could view, store and share photos digitally. The Advantix failed, but the company’s unwillingness to shift focus to digital technology continued. Kodak went from a 90% market share in US camera sales in 1976 to less than 10% in 2012, when it filed for bankruptcy. It sold off many of its biggest businesses and patents and is now a shell of its former self.

Source: Wikimedia Commons
Source: Wikimedia Commons

Few military blunders are as monumental as Napoleon’s decision to invade Russia. The military genius had conquered most of modern day Europe. However, Britain remained out of his grasp and so, he imposed a trade blockade against the island nation. But the Russia’s Czar Alexander I refused to comply due to its effect on Russian trade. To teach the Russians a lesson, Napolean assembled his Grand Armée – one of the largest forces to ever march on war. Estimates put it between 450,000 to 680,000 soldiers. Napoleon had been so successful because his army could live off the land i.e. forage and scavenge extensively to survive. This was successful in agriculture-rich and densely populated central Europe. The vast, barren lands of Russia were a different story altogether. The Russian army kept retreating further and further inland burning crops, cities and other resources in their wake to keep these from falling into French hands. A game of cat and mouse ensued with the French losing soldiers to disease, starvation and exhaustion. The first standoff between armies was the bloody Battle of Borodino which resulted in almost 70,000 casualties. Seven days later Napoleon marched into a Moscow that was a mere shell, burned and stripped of any supplies. No Russian delegation came to formally surrender. Faced with no provisions, diminished troops and a Russian force that refused to play by the rules, Napolean began the long retreat, back to France. His miseries hadn’t ended - his troops were attacked by fresh Russian forces and had to deal with the onset of an early winter. According to some, only 22,000 French troops made it back to France after the disastrous campaign.

Source: Wikimedia Commons
Source: Wikimedia Commons

When it comes to sports, few long time Indian cricket fans can remember the AustralAsia Cup final of 1986 without wincing. The stakes were extremely high – Pakistan had never won a major cricket tournament, the atmosphere at the Sharjah stadium was electric, the India-Pakistan rivalry at its height. Pakistan had one wicket in hand, with four runs required off one ball. And then the unthinkable happened – Chetan Sharma decided to bowl a Yorker. This is an extremely difficult ball to bowl, many of the best bowlers shy away from it especially in high pressure situations. A badly timed Yorker can morph into a full toss ball that can be easily played by the batsman. For Sharma who was then just 18 years old, this was an ambitious plan that went wrong. The ball emerged as a low full toss which Miandad smashed for a six, taking Pakistan to victory. Almost 30 years later, this ball is still the first thing Chetan Sharma is asked about when anyone meets him.

So, what leads to bad decisions? While these examples show the role of personal biases, inertia, imperfect information and overconfidence, bad advice can also lead to bad decisions. One of the worst things you can do when making an important decision is to make it on instinct or merely on someone’s suggestion, without arming yourself with the right information. That’s why Aegon Life puts the power in your hands, so you have all you need when choosing something as important as life insurance. The Aegon Life portal has enough information to help someone unfamiliar with insurance become an expert. So empower yourself with information today and avoid decisions based on bad advice. For more information on the iDecide campaign, see here.


This article was produced on behalf of Aegon Life by the marketing team and not by the editorial staff.